Just another bioinf blog



Blog by Michael Roach: @BeardyMcFace
email: mroach@bioinf.cc

About me

My name is Michael Roach; I’m a Research Associate (bioinformatician) at the new Flinders Accelerator for Microbiome Exploration at Flinders University (oPiNiOnS aRe My oWn).

I previously worked at the Australian Wine Research Institute where I assembled the Chardonnay genome and developed a new gold standard for grapevine clonal marker discovery. I wrote the pipeline Purge Haplotigs for heterozygous diploid assembly cleanup, and contributed to many other various yeast genomics projects etc.

My Honours and PhD was in drug discovery, not genomics, and involved identifying and testing candidate structural inhibitors of malarial enzymes which required a lot of protein homology modelling and in silico screening.

The transition from protein to DNA bioinformatics was equal parts challenging and rewarding, and I’m excited about the new move from genomics to metagenomics. My Research interests include all things bioinformatics, data viz and graphic design, software dev, and more recently webapp dev.

Outside of work I’m an enthusiast brewer and BCJP certified beer judge (bjcp.org), but wine is good too. I play video games, am a hockey goalie, and generally have too many interests and too little time.

This site is intended to be a collection of stuff I’ve done, stuff I’m doing, and stuff I think is neat. If you’re interested in what I’m doing then great! If you googled your way here to debug some perl code your supervisor gave you then, good luck!

Associations

Australian Bioinformatics And Computational Biology Society (ABACBS)

Australian Society for Biochemistry and Molecular Biology (ASBMB)

Adelaide Protein Group (committee member and webmaster; APG)

Publications

CA Onetto, SA Schmidt, MJ Roach, AR Borneman (2020), Comparative genome analysis proposes three new Aureobasidium species isolated from grape juice, FEMS Yeast Research | DOI

MJ Roach, AR Borneman, SA Schmidt (2020), Origin of Chardonnay clones with historical significance in Australia and California, Australian Journal of Grape and Wine Research | DOI

MJ Roach, AR Borneman, (2020), New genome assemblies reveal patterns of domestication and adaptation across Brettanomyces (Dekkera) species, BMC genomics 21 (1), 1-14 | DOI

AG Cordente, AR Borneman, C Bartel, D Capone, M Solomon, M Roach, C Curtin, Inactivating mutations in Irc7p are common in wine yeasts, attenuating carbon-sulfur β-lyase activity and volatile sulfur compound production, (2019), Appl. Environ. Microbiol. 85 (6), e02684-18 | DOI

C Varela, C Bartel, M Roach, A Borneman, C Curtin, (2019), Brettanomyces bruxellensis SSU1 haplotypes confer different levels of sulfite tolerance when expressed in a Saccharomyces cerevisiae SSU1 null mutant, Appl. Environ. Microbiol. 85 (4), e02429-18 | DOI | JOURNAL COVER

MJ Roach, DL Johnson, J Bohlmann, HJJ van Vuuren, SJM Jones, IS Pretorius, SA Schmidt, AR Borneman, (2018), Population sequencing reveals clonal diversity and ancestral inbreeding in the grapevine cultivar Chardonnay, PLoS genetics 14 (11), e1007807 | DOI

MJ Roach, SA Schmidt, AR Borneman, (2018), Purge Haplotigs: allelic contig reassignment for third-gen diploid genome assemblies, BMC bioinformatics 19 (1), 460 | DOI